TABLE OF CONTENT: South African Journal of Diabetes and Vascular Disease

Volume 4, Issue 2, Jun 2007

1. Title: From the editor's desk
   Authors: Mollentze, Willie
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 52
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2. Title: Diabetes in pregnancy, a challenge to Africa : edtorial
   Authors: Coetzee, Edward J.
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 53-54
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3. Title: Rosiglitazone and risk of cardiovascular disease : a storm in a teacup, or the beginning of the end? : editorial
   Authors: Koning, J.M.M.; Mollentze, W.F.
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 55-56
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4. Title: Letter to the editor : advertorial
   Authors: Singh, N.
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 57
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5. Title: Heart failure complicating acute myocardial infarction in patients with diabetes : pathophysiology and management strategies : review
   Authors: Sulfi, Sreekumar; Timmis, Adam D.
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 58-62
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   Abstract: Diabetes mellitus increases the risk of acute coronary events and is similar to that of people without diabetes who have experienced a myocardial infarction (MI). Left ventricular failure is a major contributor to the excess mortality observed in diabetic MI. This review explores this excess risk and considers strategies for its prevention and treatment.
   
6. Title: Heart failure and diabetes in primary care : review
   Authors: Kirby, Mike
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 64-69
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   Abstract: Diabetes and cardiovascular disease, such as heart failure share many common denominators and they cannot therefore be managed 'in isolation'. The management of overall cardiovascular risk is now the cornerstone to any treatment approach. With the prevalence of both diabetes and heart failure predicted to rise, in a bid to avoid the associated increase in hospital admissions, the onus for effective diagnosis and management of both of these conditions will increasingly fall to those working in primary care. This article explores the current guidelines on managing heart failure in primary care, and specifically looks at the prevention and treatment of heart failure in those with diabetes. Current guidelines recommend angiotensin-converting enzyme (ACE) inhibitors as first-line therapy for heart failure. There is good evidence for this, as well as alternative treatments for those who cannot tolerate ACE inhibitors, or who require additional treatment.
    
7. Title: Pharmacological and non-pharmacological treatment of endothelial dysfunction : relevance to diabetes : review
   Authors: Gkaliagkousi, Eugenia; Shah, Ashish; Ferro, Albert
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 70-75
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   Abstract: Vascular disease is the most important complication of both type 1 and type 2 diabetes, with both micro- and macrovascular disease underlying most of the death and disability observed in diabetic patients. Endothelial dysfunction is a cardinal feature of both types of diabetes, and is believed to be involved in the aetiology and pathophysiology of diabetic vasculopathy. Therefore, measures which improve endothelial dysfunction in diabetes are currently the subject of much interest and research. In this article, we review both drug and non-drug therapies for endothelial dysfunction, along with evidence of their effectiveness in diabetes. We suggest that those therapies for which good evidence of endothelial benefit exists should be more widely used in diabetic patients, and that the maximum benefit will be derived by using multiple such therapies in combination.
    
8. Title: Improving outcomes of pregnancy for women with type 1 and type 2 diabete : achieving best practice
   Authors: Murphy, Helen R.; Temple, Rosemary C.; Roland, Jonathan M.
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 76-80
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   Abstract: The pregnancy outcomes for women with type 1 diabetes remain poor with increased risk of major congenital malformation, stillbirth, premature delivery and perinatal death compared to the background maternity population. Despite clear evidence that women who attend prepregnancy care have improved blood glucose control with reduced risk of serious adverse outcomes, only a minority of women attend these clinics. For women with type 2 diabetes who are older, more obese and more likely to belong to an ethnic minority or live in an area of social deprivation, pregnancy outcomes are at least as poor as for women with type 1 diabetes. This is important as the prevalence of type 2 diabetes in women of reproductive years is increasing and even fewer women with type 2 diabetes attend prepregnancy care or take folic acid supplementation. Greater awareness regarding the risks among women with diabetes as well as primary and secondary healthcare professionals is required, if pregnancy outcomes are to be improved.
    
9. Title: Effect of candesartan cilexetil on carotid intima-media thickness in hypertensive type 2 diabetic patients. MITEC study : design and baseline characteristics : current topics
   Authors: Valensi, Paul; Baguet, Jean-Philippe; Asmar, Roland; Nisse-Durgeat, Sophie; Mallion, Jean-Michel
   From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
   Published: 2007
   Pages: 81-87
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   Abstract: Media Intima Thickness Evaluation of Candesartan (MITEC), a multicentre, randomised, double-blind, parallel-group study assessed the effect of candesartan cilexetil (CC) versus amlodipine (AML) administered during three years, on carotid intima-media thickness (IMT) in hypertensive type 2 diabetic patients. The study design, the baseline characteristics, and the determinants of carotid IMT are presented.
   After a placebo run-in period of four weeks, patients were randomised to CC (n=100) or AML (n=109). The mean blood pressure values were 155.9+11.0 mmHg, 91.3+8.0 mmHg and 64.6+11.8 mmHg for systolic, diastolic and pulse pressure respectively, and the mean HbA1C was 7.1+1.3%. The mean common carotid IMT was 0.74+0.16 mm. The univariate regression analyses showed a significant correlation between IMT and age (p<0.0001), gender (p=0.013) and creatinine clearance (p=0.03). Only age was significantly correlated with carotid IMT (p<0.0001) in the multivariate analysis.
   In conclusion, the MITEC population has good metabolic control at baseline where carotid IMT is mainly related with age.
    
10. Title: Insulin detemir in everyday practice : drug trends in diabetes
    From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
    Published: 2007
    Pages: 88, 90-91
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11. Title: FIELD study supports the value of fenofibrate in type 2 diabetes management : drug trends in diabetes
    From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
    Published: 2007
    Pages: 91-92
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12. Title: Special report on the sanofi-aventis cardiometabolic symposium : drug trends in diabetes
    From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
    Published: 2007
    Pages: 95-99, 103-104, 106
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13. Title: The Heartfelt Commitment campaign : diabetes news
    From: South African Journal of Diabetes and Vascular Disease, Vol 4, Issue 2, Jun
    Published: 2007
    Pages: 108
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