SAJDVD: VOLUME 20, ISSUE
2, November
2023
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- From the Editor’s Desk
Authors: Mahomed, FA
From: South African Journal of Diabetes and Vascular Disease, Vol 20, Issue 2, November 2023
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- Comparison of early postoperative results in patients with and without diabetes with low ejection fraction and normal serum creatinine values who underwent coronary artery bypass operation
Authors: CIHAN YÜCEL, İLHAN ÖZGÖL
From: South African Journal of Diabetes and Vascular Disease, Vol 20, Issue 2, November 2023
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Background: Low left ventricular ejection fraction and renal insufficiency are factors that increase the risk of coronary artery bypass graft surgery in patients with diabetes mellitus. The aim of this study was to group patients with low left ventricular ejection fraction undergoing coronary artery bypass graft surgery according to the presence or absence of diabetes mellitus and to evaluate postoperative changes in serum creatinine levels and postoperative outcomes.
Methods: A total of 93 patients undergoing isolated coronary artery bypass grafting were included in this singlecentre, retrospective, cohort study. Patients with a preoperative low left ventricular ejection fraction of less than 35% were included in the study. Patients were divided into diabetic and non-diabetic groups and intra- and intergroup values were compared. Pre-operative, and postoperative days 2 and 5 serum creatinine levels of the patients were measured and compared.
Results: Of the 93 patients included in the study, 60 were in the diabetic group (group 1) and 33 were in the non-diabetic group (group 2). Postoperative 2- and 5-day creatinine levels were significantly higher in group 1 than in group 2 (p = 0.033 and p = 0.005, respectively). Postoperative 2- and 5-day creatinine levels were significantly higher than pre-operative creatinine levels in group 1 (p = 0.008 and p = 0.001, respectively). The intensive care unit stay was significantly longer in the diabetes mellitus group than in the group without diabetes mellitus (p = 0.031).
Conclusion: Following coronary artery bypass graft surgery in patients with low left ventricular ejection fraction, which is already a risk factor, creatinine levels were found to have increased in the diabetes mellitus group.
- The cardiovascular benefits of new diabetes drugs
Authors: A MANEY, K HANMONTH
From: South African Journal of Diabetes and Vascular Disease, Vol 20, Issue 2, November 2023
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Abstract: Diabetes is associated with a significantly increased risk of cardiovascular disease. The emergence of novel antidiabetic medications not only aims to control blood glucose levels, but also shows the potential to mitigate the cardiovascular risks and long-term complications associated with the disease. The potential cardiovascular benefits and clinical implications of these antidiabetic drugs are examined in this article. The results of ongoing clinical trials and additional observational studies will further augment the development of newer drugs with added cardiovascular benefits and lead to more widespread use of these newer agents. This was a secondary analysis of various trials using new diabetes drugs, focusing on cardiovascular benefits and safety profile. Among these new antidiabetic drugs, sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide-1 receptor agonists have been shown to be effective in reducing major adverse cardiovascular events. Conversely, dipeptidyl peptidase-4 inhibitors, although effective in controlling blood glucose levels, have not consistently shown significant cardiovascular benefits.
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- Microalbuminuria and left ventricular dysfunction in type 2 diabetes
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RELIABLE EXPERT INFORMATION
The SAJDVD’s main focus is
providing new and relevant information for doctors,
nurses and allied professionals involved in caring
for the diabetes patient.
But as we are part of the larger Diabetes team, we would like to reach out to all patients with relevant information. So here it is!
But as we are part of the larger Diabetes team, we would like to reach out to all patients with relevant information. So here it is!
